所在学科专业：

病理学

研究方向：

1. 肿瘤分子病理学 2. 基因组稳定性与肿瘤 3.细胞代谢与肿瘤

讲授课程：

教育经历：

1982年9 月至1987 年7 月 学生苏州医学院医疗系 医学学士学位

1987年9 月至1990 年7 月 学生 南通医学院病理生理学 医学硕士学位

1997年9 月至2000 年6 月 学生苏州大学（苏州医学院）医学博士学位

2001年2 月至2004 年11 月 博士后 美国德州大学M.D. Anderson癌症中心分子病理学系

工作经历：

1990年7 月至1993 年8 月 助教，住院医师，苏州医学院附二院内科

1993年9 月至1999 年8 月 讲师，主治医师，苏州医学院附二院内科

1999年9 月至2001 年1 月 副教授，副主任医师，苏州医学院附二院内科

2004年12 月至2009 年11 月 助理教授（研究）美国德州大学M.D. Anderson

癌症中心分子治疗系（系统生物学系）

2009年11 月月至2014 年5 月助理教授（Tenure-track）美国阿拉巴马大学医学院医学系血液和肿瘤科

科研项目：

以独立 PI身份，获得 NIH R 01基金、 SPORE及国家自然科学基金等多项资助。

学术论文：

1. Wang YS, Chen J, Cui F, Wang H, Wang S, Hang W, Zeng Q, Quan CS, Zhai YX, Wang JW, Shen XF, Jian YP, Zhao RX, Werle KD, Cui R, Liang J, Li Y,Xu ZX. LKB1 is a DNA damage response protein that regulates cellular sensitivity to PARP inhibitors.Oncotarget. 2016 Sep 29. doi: 10.18632/oncotarget.12334.

2. Zeng Q, Chen J, Li Y, Werle KD, Zhao RX, Quan CS, Wang YS, Zhai YX, Wang JW, Youssef M, Cui R, Liang J, Genovese N, Chow LT, Li YL,Xu ZX.LKB1 inhibits HPV-associated cancer progression by targeting cellular metabolism. Oncogene. 2016 Aug 22. doi: 10.1038/onc.2016.290. [Epub ahead of print]

3. Zeng Q, Zhao RX, Chen J, Li Y, Li XD, Liu XL, Zhang WM, Quan CS, Wang YS, Zhai YX, Wang JW, Youssef M, Cui R, Liang J, Genovesee N,ChowLT, Li YL,Xu ZX.O-linked GlcNAcylation elevated by HPV E6 mediates viral oncogenesis.Proc Natl Acad Sci U S A. 2016; 113(33): 9333-8.

4. Daniel Klionsky, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).Autophagy.2016; 12(1): 1-222.

5. Li X, Miao X, Wang H,Xu ZX, Li B. The tissue dependent interactions between p53 and bcl-2in vivo.Oncotarget.2015; 6(34):35699-709.

6. Cao J, Wan L, Dai X, Wang H, Zhang Z, Xuan Z,Xu, ZX, Xu X, Hinds P, Flaherty K, Faller D, Goding C, Wang J, Wei W, Cui R. The E3 ligase APC/C^Cdh1 promotes ubiquitylation-mediated proteolysis of PAX3 to suppress melanocyte proliferation and melanoma growth.Science Signaling.2015; 8(392): ra87

7. Liang J, Xu ZX, Ding Z, Lu Y, Yu Q, Werle KD, Zhou G, Park YY, Peng G, Gambello MJ, Mills GB.Myristoylation confers noncanonical AMPK functions in autophagy selectivity and mitochondrial surveillance.Nature Communications. 2015; 6: 7926.

8. Jin L andXu ZX. Recent advances in the study of HPV-associated carcinogenesis.Virologica Sinica.2015;30 (2): 101-106

9. Xi Y, Gao H, Callaghan MU, Fribley AM, Garshott DM,Xu ZX, Zeng Q, Li YL.Induction of BCL2-Interacting Killer, BIK, is Mediated for Anti-Cancer Activity of Curcumin in Human Head and Neck Squamous Cell Carcinoma Cells.J Cancer. 2015; 6(4): 327-332.

10. Xu HG, Zhai YX, Chen J, Lu Y, Wang JW, Quan CS, Zhao RX, Xiao X, He Q, Werle KD, Kim HG, Lopez R, Cui R, Liang J, Li YL,Xu ZX. LKB1 reduces ROS-mediated cell damage via activation of p38.Oncogene.2015; 34(29): 3848-3859.

11. Jian W,Xu HG,Chen J,Xu ZX,Levitt JM,Stanley JA,Yang ES,Lerner SP,Sonpavde G. Activity of CEP-9722, a poly (ADP-ribose) polymerase inhibitor, in urothelial carcinoma correlates inversely with homologous recombination repair response to DNA damage.Anticancer Drugs.2014; 25: 878-886.

12. Werle KD, Chen J, Xu HG, Zhao RX, Cui R, Liang J,Xu ZX. Liver Kinase B1 regulates the centrosome via PLK1.Cell Death Disease2014; 5: e1157 (11 pages).

13. Zhao RX, Xu ZX. Targeting the LKB1 Tumor Suppressor.Current Drug Targets 2014; 15: 32-52.

14. Lu C, Chen J, Xu HG, Zhou X, He Q, Li YL, Jiang G, Shan Y, Xue B, Zhao RX, Wang Y, Werle KD, Cui R, Liang J,Xu ZX.MIR106B and MIR93 Prevent Removal of Bacteria from Epithelial Cells by Disrupting ATG16L1-Mediated Autophagy.Gastroenterology2014; 146: 188-199.

15. Wang Y, Wang JW, Xiao X, Shan Y, Xue B, Jiang G, He Q, Chen J, Xu HG, Zhao RX, Werle KD, Cui R, Liang J, Li YL,Xu ZX. Piperlongumine induces autophagy by targeting p38 signaling.Cell Death Disease2013; 4: e824 (11 pages).

16. Liu F, Cao J, Sullivian K, Shen J, Ryu B,Xu ZX, Liu X, Cui R. Stat3 targeted therapies overcome the acquired resistance to vemurafenib in melanomas.J Invest Dermatol2013; 133: 2041-2049.

17. Liu F, Cao J, Lv J, Dong L, Pier E, Xu GX, Wang RA,Xu ZX, Goding C, Cui R.TBX2 expression is regulated by PAX3 in the melanocyte lineage.Pigment Cell Melanoma Res2013; 26: 67-77.

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